Pedraza LK, Sierra RO, de Oliveira Alvares L. Systems consolidation and fear memory generalisation as a potential target for trauma-related disorders. World J Biol Psychiatry. 2022 Jan 21:1-13. doi: 10.1080/15622975.2022.2027010. Epub ahead of print. PMID: 35001808.

Takeuchi Y, Harangozó M, Pedraza L, Földi T, Kozák G, Li Q, Berényi A. Closed-loop stimulation of the medial septum terminates epileptic seizures. Brain. 2021 Apr 12;144(3):885-908. doi: 10.1093/brain/awaa450. PMID: 33501929.

Duran JM, Sierra RO, Corredor K, Cardenas FP. Cathodal transcranial direct current stimulation on the prefrontal cortex applied after reactivation attenuates fear memories and prevent reinstatement after extinction. J Psychiatr Res. 2021 Dec 15;145:213-221. doi: 10.1016/j.jpsychires.2021.12.025. Epub ahead of print. PMID: 34929471.

llescas-Huerta E, Ramirez-Lugo L, Sierra RO, Quillfeldt JA, Sotres-Bayon F. Conflict Test Battery for Studying the Act of Facing Threats in Pursuit of Rewards. Front Neurosci. 2021 May 4;15:645769. doi: 10.3389/fnins.2021.645769. PMID: 34017234; PMCID: PMC8129192.

Pedraza, L. K., Sierra, R. O., Giachero, M., Nunes-Souza, W., Lotz, F. N., & de Oliveira Alvares, L. (2019). Chronic fluoxetine prevents fear memory generalization and enhances subsequent extinction by remodeling hippocampal dendritic spines and slowing down systems consolidation. Translational psychiatry, 9(1), 53. doi:10.1038/s41398-019-0371-3

Pedraza, L. K., Sierra, R. O., Lotz, F. N., & Alvares, L. O. (2018). Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats. Sci.Rep., 8, 7260.

Crestani, A. P., Sierra, R. O., Machado, A., Haubrich, J., Scienza, K. M., de Oliveira, A. L. et al. (2018). Hippocampal plasticity mechanisms mediating experience-dependent learning change over time. Neurobiol.Learn.Mem., 150, 56-63.

Haubrich J, Machado A, Boos FZ, Crestani AP, Sierra RO, Alvares LO, Quillfeldt JA (2017) Enhancement of extinction memory by pharmacological and behavioral interventions targeted to its reactivation. Scientific Reports. 2017 Sep 8;7(1):10960. doi: 10.1038/s41598-017-11261-6.

Sierra RO, Pedraza LK, Santana F, Boos FZ, Crestani AP, Haubrich J, de Oliveira AL, Quillfeldt JA (2017) Reconsolidation–induced rescue of a remote fear memory blocked by an early cortical inhibition: involvement of the Anterior Cingulate Cortex is mediated by the thalamic Nucleus Reuniens. Hippocampus. May;27(5):596-607. doi: 10.1002/hipo.22715

Lunardi P, Sachser RM, Sierra RO, Pedraza LK, Medina C, de lF, V, Romano A, Quillfeldt JA, de Oliveira AL (2017) Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction. Molecular Neurobiology . 2017 Jan 13. doi: 10.1007/s12035-016-0361-x

Pedraza LK, Sierra RO, Crestani AP, Quillfeldt JA, de Oliveira AL (2017) Sequential learning during contextual fear conditioning guides the rate of systems consolidation: Implications for consolidation of multiple memory traces. Hippocampus. 2017 May;27(5):518-528. doi: 10.1002/hipo.22708

Santana F, Sierra RO, Haubrich J, Crestani AP, Duran JM, de Freitas CL, de Oliveira AL, Quillfeldt JA (2016) Involvement of the infralimbic cortex and CA1 hippocampal area in reconsolidation of a contextual fear memory through CB1 receptors: Effects of CP55,940. Neurobiology of Learning and Memory. 127:42-47. doi: 10.1016/j.nlm.2015.11.016.

Crestani AP, Zacouteguy BF, Haubrich J, Sierra RO, Santana F, Molina JM, Cassini LF, Alvares LO, Quillfeldt JA (2015) Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation. Scientific Reports 5:13633. doi: 10.1038/srep13633.

Pedraza LK, Sierra RO, Boos FZ, Haubrich J, Quillfeldt JA, de Oliveira AL (2015) The dynamic nature of systems consolidation: Stress during learning as a switch guiding the rate of the hippocampal dependency and memory quality. Hippocampus. 2016 Mar;26(3):362-71. doi: 10.1002/hipo.22527.

Sierra RO, Nitola LP, Duran JM, Prieto DR, Leon LA, Cardenas FP (2015) Medial orbitofrontal cortex lesion prevents facilitatory effects of d-cycloserine during fear extinction. Behavioural Brain Research. 2016 Jan 1;296:379-83. doi: 10.1016/j.bbr.2015.08.021.

Haubrich J, Crestani AP, Cassini LF, Santana F, Sierra RO, Alvares Lde O, Quillfeldt JA (2015) Reconsolidation allows fear memory to be updated to a less aversive level through the incorporation of appetitive information. Neuropsychopharmacology. Jan;40(2):315-26. doi: 10.1038/npp.2014.174.

Sierra RO, Cassini LF, Santana F, Crestani AP, Duran JM, Haubrich J, de Oliveira Alvares L, Quillfeldt JA (2013) Reconsolidation may incorporate state-dependency into previously consolidated memories. Learning and Memory. Jun 19;20(7):379-87. doi: 10.1101/lm.030023.112.

Cassini LF, Sierra RO, Haubrich J, Crestani AP, Santana F, de Oliveira Alvares L, Quillfeldt JA (2013) Memory reconsolidation allows the consolidation of a concomitant weak learning through a synaptic tagging and capture mechanism. Hippocampus. Oct;23(10):931-41. doi: 10.1002/hipo.22149.

Leon LA ; LIZARASO, LT ; Sierra RO ; Nitola LP ; Urazan JC ; CARDENAS, FP (2010) Effect of Acute Fluoxetine Application on a Context Fear Conditioned Task in Behaviorally Restrained Rats. Universitas Psychologica, v. 9, p. 689-696.

Aquí encontrarás las referencias de algunos de los trabajos científicos en los que hemos participado a lo largo de nuestra carrea